کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365935 981577 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses
چکیده انگلیسی

A novel series of potent C-6 substituted pyrazolo[1,5-a]pyridine inhibitors of herpes simplex viruses has been identified. A synthetic methodology was developed involving functionalization of a C-6 trifluoromethyl pyrazolo[1,5-a]pyridine to allow facile access to a diverse set of analogues from common late stage intermediates. The expansion of the SAR of this series at the 6 position allows for modifications to developability parameters such as clog P, while maintaining potency comparable to acyclovir.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 4, 15 February 2006, Pages 944–954
نویسندگان
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