Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1

Soluble guanylate cyclase (sGC) is activated by the known benzylindazole derivative YC-1 [1-benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole]. YC-1 also acts synergistically with CO, activating sGC to a level comparable to that achieved upon binding of nitric oxide, the endogenous activator of sGC. We here describe the synthesis of a YC-1 phosphonate analogue with improved aqueous solubility as well as its effects on sGC.

The synthesis and testing of a phosphonate analogue of the soluble guanylate cyclase (sGC) activator YC-1 is described. With enhanced aqueous solubility, the effects of this analogue on sGC are reported.Figure optionsDownload as PowerPoint slide