کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366099 981580 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
چکیده انگلیسی

A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 17, 1 September 2007, Pages 4967–4971
نویسندگان
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