Pyrazolone methylamino piperidine derivatives as novel CCR3 antagonists

The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.

The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given.Figure optionsDownload as PowerPoint slide