کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366557 981595 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enzymatic synthesis of arbutin undecylenic acid ester and its inhibitory effect on melanin synthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Enzymatic synthesis of arbutin undecylenic acid ester and its inhibitory effect on melanin synthesis
چکیده انگلیسی

Transesterification of arbutin and undecylenic acid vinyl ester was catalyzed by alkaline protease, Bioprase, in dimethylformamide to get arbutin derivative having undecylenic acid at 6-position of glucose moiety, 6-O-undecylenoyl p-hydroxyphenyl β-d-glucopyranoside. The reaction rate increased with increase of arbutin concentration, and when its concentration was 0.9 M, the conversion rate was more than 90% under addition of 2 M undecylenic acid vinyl ester. The obtained arbutin ester significantly suppressed melanin production in murine B16 melanoma cells.

Transesterification of arbutin and undecylenic acid vinyl ester was catalyzed by protease to get arbutin derivative having undecylenic acid ester. The arbutin ester significantly suppressed melanin production in murine B16 melanoma cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3105–3108
نویسندگان
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