2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents

A series of 2,4,6-trisubstituted pyrimidine derivatives was synthesized and evaluated for their in vivo pregnancy interceptive activity in hamsters. Out of the 17 compounds synthesized three compounds showed 100% activity at a dose of 10 mg/kg.

A series of 2,4,6-trisubstituted-pyrimidine derivatives were synthesized and evaluated for their in vivo pregnancy interceptive activity.Figure optionsDownload as PowerPoint slide