کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366627 981597 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase
چکیده انگلیسی

A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl)boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2-boronic acid were found to be the most potent HSL inhibitors with IC50 values of 140, 17 and 350 nM, respectively.

A range of aryl and heteroaryl boronic acids were tested for their in vitro hormone-sensitive lipase inhibitory properties. (2-Benzyloxy-5-fluorophenyl)boronic acid, (2-benzyloxy-5-chlorophenyl)boronic acid and 5-bromothiophene-2-boronic acid were found to be the most potent HSL inhibitors with IC50 values of 140, 17 and 350 nM, respectively.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 6, 15 March 2005, Pages 2305–2312
نویسندگان
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