کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366699 981600 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of 12 allenic aromatic ethers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of 12 allenic aromatic ethers
چکیده انگلیسی

Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure–activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.

Twelve allenic aromatic ethers (2 and 3), some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The structure–activity relationships suggested that the introduction of allenic moiety to the phenol hydroxyl group could generate or enhance cytotoxicity of these phenol compounds.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 10, 15 May 2007, Pages 2785–2788
نویسندگان
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