کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1366699 | 981600 | 2007 | 4 صفحه PDF | دانلود رایگان |

Twelve allenic aromatic ethers, some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The analysis of structure–activity relationships suggested that the introduction of allenic moiety could generate or enhance cytotoxicity of these phenol compounds.
Twelve allenic aromatic ethers (2 and 3), some of them are natural products isolated from the mangrove fungus Xylaria sp. 2508 in the South China Sea, were synthesized. Their antitumor activities against KB and KBv200 cells were determined. All these compounds demonstrated cytotoxic potential, ranging from weak to strong activity. The structure–activity relationships suggested that the introduction of allenic moiety to the phenol hydroxyl group could generate or enhance cytotoxicity of these phenol compounds.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 10, 15 May 2007, Pages 2785–2788