کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366726 | 981600 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective and dual action orally active inhibitors of thrombin and factor Xa
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selective and dual action orally active inhibitors of thrombin and factor Xa Selective and dual action orally active inhibitors of thrombin and factor Xa](/preview/png/1366726.png)
چکیده انگلیسی
The synthetic entry to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability is described. This was achieved through minor modifications to the sulfonamide group in our potent and selective fXa inhibitor (E)-2-(5-chlorothien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-(morpholin-4-yl)-2-oxoethyl]-2-oxopyrrolidin-3-yl}ethenesulfonamide and these observed activity changes have been rationalised using structural studies.
The synthetic entry to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability is described. The observed activity changes have been rationalised using structural studies.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 10, 15 May 2007, Pages 2927–2930
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 10, 15 May 2007, Pages 2927–2930
نویسندگان
Robert J. Young, David Brown, Cynthia L. Burns-Kurtis, Chuen Chan, Máire A. Convery, Julia A. Hubbard, Henry A. Kelly, Anthony J. Pateman, Angela Patikis, Stefan Senger, Gita P. Shah, John R. Toomey, Nigel S. Watson, Ping Zhou,