Keywords: بازدارنده دوگانه; Colchicine; Dual inhibitor; HDAC; Tubulin; Hybrid;
مقالات ISI بازدارنده دوگانه (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: بازدارنده دوگانه; AKT inhibitor; autoimmune adverse effects; autoimmune dermopathies; B-RAF; dabrafenib; dermatitis; dual inhibitor; dysgeusia; everolimus; hair loss; hedgehog signaling pathway; immunotherapy; immune-related toxicities; ipilimumab; keratoacanthoma; keratos
Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors
Keywords: بازدارنده دوگانه; Topoisomerase; Histone deacetylase; Dual inhibitor; Drug design; Anticancer;
Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27
Keywords: بازدارنده دوگانه; Chondrosarcoma; OUMS-27; mTOR inhibitor; Rapamycin; MEK inhibitor; PD 0325901; Dual inhibitor; Synergistic effect;
Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold
Keywords: بازدارنده دوگانه; 1H-Indazol-3-amine and benzohydroxamic acids hybrids; HDACs; FGFR1; Dual inhibitor; MCF-7;
A novel NAE/UAE dual inhibitor LP0040 blocks neddylation and ubiquitination leading to growth inhibition and apoptosis of cancer cells
Keywords: بازدارنده دوگانه; NEDD8 activating enzyme; Ubiquitin activating enzyme; Dual inhibitor; Apoptosis; Drug discovery;
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs
Keywords: بازدارنده دوگانه; Heat shock protein 90 (Hsp90); Tyrosine kinase ALK; Dual inhibitor; Drug resistance; Antiproliferative activity;
Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R
Keywords: بازدارنده دوگانه; 2,4-Diarylaminopyrimidine; Dual inhibitor; ALK; ROS1; Crizotinib-resistant;
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRAFV600E and VEGFR-2 dual inhibitors
Keywords: بازدارنده دوگانه; Dual inhibitor; BRAFV600E; VEGFR-2; 1H-pyrazolo[3,4-d]pyrimidine; Tyrosine kinase;
Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors
Keywords: بازدارنده دوگانه; Pyrido[3,2-d]pyrimidine; Pyrido[2,3-d]pyrimidine phosphoinositide; 3-Kinase alpha; mTOR; Dual inhibitor;
(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1
Keywords: بازدارنده دوگانه; (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime; Hyperuricemia; Xanthine oxidase; Urate transporter 1; Dual inhibitor;
Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia
Keywords: بازدارنده دوگانه; Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely
Keywords: بازدارنده دوگانه; Antimalarial drug; Plasmodium falciparum; FP-2; PfDHFR; Dual inhibitor;
5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes
Keywords: بازدارنده دوگانه; Benzimidazole; In vitro; Urease; α-glucosidase; Dual inhibitor; Structure-activity relationship; Thiourea; Cytotoxicity; In silico;
Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment
Keywords: بازدارنده دوگانه; Lysine-specific demethylase 1; Histone deacetylases; Dual inhibitor; Synthesis;
Discovery of a potent dual ALK and EGFR T790M inhibitor
Keywords: بازدارنده دوگانه; ALK; EGFR T790M; Dual inhibitor; Non-small cell lung cancer; Rational drug design;
Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication
Keywords: بازدارنده دوگانه; Sennoside A; HIV-1; Reverse transcriptase; Antiviral activity; Plant extracts; Dual inhibitor; DKA; diketo acid; EC50; HIV-1 replication by 50%; HAART; Highly Active Anti-Retroviral Therapy; HIV-1; Human Immunodeficiency Virus type 1; IN; integrase; INIs;
Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs
Keywords: بازدارنده دوگانه; VEGFR; c-Met; Dual inhibitor; Anti-cancer drugs
Design, synthesis and biological evaluation of novel 4-arylaminopyrimidine derivatives possessing a hydrazone moiety as dual inhibitors of L1196M ALK and ROS1
Keywords: بازدارنده دوگانه; 4-Arylaminopyrimidine derivatives; Hydrazone moiety; Dual inhibitor; L1196M ALK; ROS1;
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC
Keywords: بازدارنده دوگانه; N-Phenylquinazolin-4-amine hybrid; VEGFR-2; HDAC; Dual inhibitor
2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFRL858R/T790M
Keywords: بازدارنده دوگانه; EGFR; IGF1R; NSCLC; Dual inhibitor;
Synthesis and structure–activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives
Keywords: بازدارنده دوگانه; Phosphoinositide 3-kinase; Mammalian target of rapamycin; Dual inhibitor; Anti-tumor activity
Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors
Keywords: بازدارنده دوگانه; Phosphoinositide 3-kinase; Mammalian target of rapamycin; Dual inhibitor; Anti-tumor activity;
Dietary flavonoids fisetin and myricetin: Dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II
Keywords: بازدارنده دوگانه; Dietary flavonoids; Falcipain-2; Plasmepsin II; Dual inhibitor;
Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach
Keywords: بازدارنده دوگانه; Phosphoinositide 3-kinase; Romidepsin; Dual inhibitor; Computational docking; Molecular superposition; Molecular dynamics simulation;
Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2
Keywords: بازدارنده دوگانه; Quinazoline; Benzimidazole; Dual inhibitor; c-Met; VEGFR-2
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
Keywords: بازدارنده دوگانه; CCR3; H1; Receptor antagonist; Dual inhibitor; Chemokine antagonist; Allergic disease;
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I
Keywords: بازدارنده دوگانه; CCR3; H1; Receptor antagonist; Dual inhibitor; Chemokine antagonist; Allergic disease;
Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent
Keywords: بازدارنده دوگانه; Falcipain-2; Dihydrofolate reductase; Dual inhibitor; Antimalarial drug; SAR; Molecular docking;
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
Keywords: بازدارنده دوگانه; PI3Kα; mTOR; Cancer; Kinase inhibitor; Dual inhibitor; Methylpyrido pyrimidinone; Physicochemical property based optimization
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process
Keywords: بازدارنده دوگانه; HIV-1 integrase; INSTI; IN-LEDGF/p75; Dual inhibitor;
Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design
Keywords: بازدارنده دوگانه; Apoptosis; Mcl-1; Bcl-2; p2 pocket; Dual inhibitor
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors
Keywords: بازدارنده دوگانه; Cyclooxygenase-2; 5-Lipoxygenase; Structure-activity relationship; Dual inhibitor;
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
Keywords: بازدارنده دوگانه; Inosine monophosphate dehydrogenase; Histone deacetylase; Dual inhibitor; Cinnamic hydroxamic acid; Cancer therapy; Drug resistance
Synthetic strategies toward carbocyclic purine–pyrimidine hybrid nucleosides
Keywords: بازدارنده دوگانه; Carbocyclic; Purine; Pyrimidine; Nucleosides; Hybrid; Dual inhibitor
Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent
Keywords: بازدارنده دوگانه; Top I, topoisomerase I; CPT, camptothecin; PLDBs, protein-linked DNA breaksTopoisomerase I; Tubulin; Dual inhibitor
Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid
Keywords: بازدارنده دوگانه; HIV-1; Capsid; Cyclophilin A; Assembly; Disassembly; Dual inhibitor
Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
Keywords: بازدارنده دوگانه; AD; AChE; BACE-1; Dual inhibitor; HE; HMC; HEA
Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase
Keywords: بازدارنده دوگانه; HIV; Reverse transcriptase; Integrase; Dual inhibitor; Rational design
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS
Keywords: بازدارنده دوگانه; c-Src; iNos; Dual inhibitor; Anti-cancer
Selective and dual action orally active inhibitors of thrombin and factor Xa
Keywords: بازدارنده دوگانه; Factor Xa; Thrombin; Oral; Dual inhibitor
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues
Keywords: بازدارنده دوگانه; COX-2; 5-LOX; Dual inhibitor; NSAIDs; DHDMBF; Homology modeling; Docking; 3D-QSAR; CoMFA; CoMSIA
Remarkable substituent effect: β-aminosquamocin, a potent dual inhibitor of mitochondrial complexes I and III
Keywords: بازدارنده دوگانه; Annonaceous acetogenins; Squamocin; Cytotoxicity; Dual inhibitor; Complex I; Complex III;
Synthetic heparin derivatives as new anticoagulant drugs
Keywords: بازدارنده دوگانه; Drug Discovery; Pharmaceutical Science; Biochemistry; Chemical Biology; Thrombosis; Oligosaccharide; Factor Xa; Dual inhibitor; Peptidomimetic; Thrombocytopenia;