Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors

Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 27, Issue 14, 15 July 2017, Pages 3117-3122

Aisha A.K. Al-Ashmawy, Fatma A. Ragab, Khaled M. Elokely, Manal M. Anwar, Oscar Perez-Leal, Mario C. Rico, John Gordon, Eugeney Bichenkov, George Mateo, Emad M.M. Kassem, Gehan H. Hegazy, Magid Abou-Gharbia, Wayne Childers,