Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors

The structure-activity relationship of a series of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives was studied. 6-Nitro group was crucial for dual COX-2/5-LOX inhibitory activity. The most potent compound 30c exhibited anti-inflammatory activity in the carrageenan-induced paw edema assay in male Wistar rats.