کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366813 981606 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists
چکیده انگلیسی

Sulfonamide analogues of the potent CB1R inverse agonist taranabant were prepared and optimized for potency and selectivity for CB1R. They were variably more potent than the corresponding amide analogues. The most potent representative 22 had good pharmacokinetic and brain levels, but was modestly active in blocking CB1R agonist-mediated hypothermia.

Sulfonamide analogues of the potent CB1R inverse agonist 2 (Taranabant) were optimized for CB1R activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2184–2187
نویسندگان
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