کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366825 | 981606 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DNA microarray analysis comparing human tumor tissues with normal tissues including hematopoietic progenitor cells resulted in identification of membrane dipeptidase as a prodrug activation enzyme. Novel prodrugs of 2′-deoxy-2′-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety.
The novel prodrugs of DMDC including compound 23 that are activated by membrane dipeptidase preferentially in tumor tissue are designed and synthesized.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2241–2245
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2241–2245
نویسندگان
Yasunori Kohchi, Kazuo Hattori, Nobuhiro Oikawa, Eisaku Mizuguchi, Yoshiaki Isshiki, Kohsuke Aso, Kiyoshi Yoshinari, Haruyoshi Shirai, Masanori Miwa, Yukiko Inagaki, Masako Ura, Kotaroh Ogawa, Hisafumi Okabe, Hideo Ishitsuka, Nobuo Shimma,