کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366851 981606 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity
چکیده انگلیسی

A series of potent 2-carboxychromone-based melanin-concentrating hormone receptor 1 (MCHr1) antagonists were synthesized and evaluated for hERG (human Ether-a-go-go Related Gene) channel affinity and functional blockade. Basic dialkylamine-terminated analogs were found to weakly bind the hERG channel and provided marked improvement in a functional patch-clamp assay versus previously reported antagonists of the series.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2365–2371
نویسندگان
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