Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2–P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavailability than the starting ketone.

Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2–P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better oral bioavailability than the starting ketone.Figure optionsDownload as PowerPoint slide