کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367062 981615 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure
چکیده انگلیسی

Structure–activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2 Å, and confirmed the design.

The follow-up designs and more detailed SAR of thiazolone derivatives as novel inhibitors of HCV NS5B polymerase were described. The X-ray complex structure for the new inhibitor was obtained at a resolution of 2.2 Å, and confirmed the design.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 1, 1 January 2007, Pages 63–67
نویسندگان
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