Estrogen receptor β ligands: Design and synthesis of new 2-phenyl-isoindole-1,3-diones

The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.

The design, synthesis and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.Figure optionsDownload as PowerPoint slide