کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367161 | 981621 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure–activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.
The compounds whose metal complexes had high SOD-like activity, 2,2′-biquinoline, cimetidine, and TPEN, had values of 50%-inhibitory concentration for PrP-res formation (IC50) of <10 nM in ScN2a cells.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 5982–5987
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 5982–5987
نویسندگان
Tomoko Fukuuchi, Katsumi Doh-ura, Shin’ichi Yoshihara, Shigeru Ohta,