کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367181 981621 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microwave expedited synthesis of 5-aminocamptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1α
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Microwave expedited synthesis of 5-aminocamptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1α
چکیده انگلیسی

A series of 5-aminosubstituted camptothecin analogs were prepared from the corresponding 5-hydroxycamptothecin using microwave irradiation. The analogs were assayed for ability to inhibit the action of hypoxia inducible factors (HIF-1α and HIF-2α). The 5-fluoroethyl analog showed potent inhibitory activity and is now the focus of ongoing pathway analysis and potential as an antiproliferative agent.

A series of 5-aminosubstituted camptothecin analogs were prepared using microwave accelerated synthesis. A fluoroethyl derivative showed superior inhibitory activity to camptothecin against the hypoxia inducible factor HIF-1α.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6082–6085
نویسندگان
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