کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367302 981625 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A protein kinase signal-responsive gene carrier modified RGD peptide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A protein kinase signal-responsive gene carrier modified RGD peptide
چکیده انگلیسی

We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

Development and evaluation of RGD peptide modified signal-responsive gene carrier are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 22, 15 November 2006, Pages 5740–5743
نویسندگان
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