کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367318 | 981625 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A set of novel borrelidin analogues have been prepared by precursor-directed biosynthesis. Structure–activity relationship analysis suggests that steric structural arrangement within the C17 side chain is important for differentiating cytotoxic and anti-angiogenic activities. A C17-cyclobutyl analogue 3 was found to have markedly increased selectivity for in vitro angiogenesis inhibition over cytotoxicity and is therefore potentially useful as an anticancer agent.
An SAR analysis of borrelidin analogues is presented.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 22, 15 November 2006, Pages 5814–5817
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 22, 15 November 2006, Pages 5814–5817
نویسندگان
Barrie Wilkinson, Matthew A. Gregory, Steven J. Moss, Isabelle Carletti, Rose M. Sheridan, Andrew Kaja, Michael Ward, Carlos Olano, Carmen Mendez, José A. Salas, Peter F. Leadlay, Rob vanGinckel, Ming-Qiang Zhang,