Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome

The five most potent peptides derive from different regions of the HIV-1 HXB2 Pol genome. Numbers adjacent to each peptide sequence indicate amino acid spans of the respective subunits on the Pol polypeptide (Numbering according to the HXB2 Numbering Engine nomenclature, Los Alamos National Laboratory). Numbers in parentheses indicate the number of the peptide (domains not drawn to scale).