Interaction of bulged DNA with leucine-containing mimics of NCS-chrom

Synthesis of chiral spirocyclic helical compounds containing leucine that mimic the core of DNA bulge binder NCSi-gb has been described. The interaction between the compounds and DNA was studied by circular dichroism (CD). The results suggested that the two synthetic diastereoisomers 7 and 8 specifically targeted the bulge site of DNA and induced conformational change of bulged DNA greatly.