Anion of hypericin is crucial to understanding the photosensitive features of the pigment

Photosensitive behaviors of hypericin (HYP) have attracted much attention, because of HYP’s great potential in photodynamic therapy. It has been found that HYP differs from homologous pigments, such as hypocrellin A (HA), in photosensitive features. For instance, despite the comparable triplet state quantum yields, HYP holds a much lower singlet oxygen yield than HA. To understand the unique photosensitive behaviors of HYP, time-dependent density functional theory is employed to calculate a series of excited-state properties of HYP and its anion (dominant in polar solvents), which are then compared with excited-state properties of HA. It is revealed that the stronger electron-donating power of HYP anion than that of HA is responsible for the HYP’s photosensitive features.

By means of time-dependent density functional theory calculations, it is revealed that the anion of hypericin, derived from proton dissociation in the bay region, is responsible for the photosensitive features of the pigment.Figure optionsDownload as PowerPoint slide