کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367625 981641 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum
چکیده انگلیسی

Haloxysterols A–D (1–4), new C-24 alkylated sterols, have been isolated from the chloroform soluble fraction of Haloxylon recurvum, along with five known sterols 5–9, which are reported for the first time from this species. Their structures were determined by means of 1D- and 2D-NMR techniques. Compounds 1–9 inhibited cholinesterase enzymes in a concentration-dependent manner with Ki values ranging between 0.85–25.5 and 1.0–19.0 μM against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively. Lineweaver–Burk, Dixon plots and their secondary replots indicated that compounds 1–9 are non-competitive inhibitors of both AChE and BChE enzymes.

Haloxysterols A–D (1–4), together with 5 known sterols (5–9), were isolated from the whole plant of Haloxylon recurvum. The structures were elucidated on the basis of spectral methods, especially 2D-NMR spectra (HMQC, HMBC, and NOESY). All the compounds showed potent inhibitory activity against cholinesterase enzyme.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 3, 1 February 2006, Pages 573–580
نویسندگان
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