کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367854 981650 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities
چکیده انگلیسی

Nineteen compounds of various classes, such as flavonoid glycosides, pterocarpanoids, lipids, glycolipids, and alkaloids, were isolated and identified from the Desmodium gangeticum whole plant. Aminoglucosyl glycerolipid (8) is reported here for the first time. Its structure has been elucidated by spectroscopic and degradation studies. This novel compound exhibited in vitro antileishmanial and immunomodulatory activities, as it enhanced nitric oxide (NO) production and provided resistance against infection established in peritoneal macrophages by the protozoan parasite Leishmania donovani. Another known compound, glycosphingolipid (cerebroside) (7) was found to possess significant in vitro antileishmanial and immunomodulatory activities against the same parasite. Other compounds were found to be inactive.

Two glycolipids were identified from Desmodium gangeticum to possess antileishmanial and immunomodulatory activities. Aminoglucosyl-glycerolipid (8) was found to be novel.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 20, 15 October 2005, Pages 4543–4546
نویسندگان
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