کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367961 | 981655 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological activity of mustard derivatives of combretastatins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biological activity of mustard derivatives of combretastatins Synthesis and biological activity of mustard derivatives of combretastatins](/preview/png/1367961.png)
چکیده انگلیسی
A series of chimeric compounds bearing the combretastatin and the nitrogen mustard cores were synthesized. All the compounds were cytotoxic and inhibited tubulin polymerization. When combretastatin was joined to chlorambucil via an ester linkage, the resultant compound proved to be significantly more potent than the two compounds put together. When combretastatin was joined to nitrogen mustard via an ether linkage or when a true hybrid was synthesized, loss of potency was observed. Nonetheless, these latter compounds appeared to be more efficacious and surprisingly were able to inhibit tubulin depolymerization at high concentrations.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 15, 1 August 2005, Pages 3551–3554
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 15, 1 August 2005, Pages 3551–3554
نویسندگان
Beatrice Coggiola, Francesca Pagliai, Gianna Allegrone, Armando A. Genazzani, Gian Cesare Tron,