کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1367967 | 981655 | 2005 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide](/preview/png/1367967.png)
A new biodegradable water-soluble phosphazene trimer–doxorubicin conjugate was synthesized, in which equimolar hydrophilic methoxy-poly(ethylene glycol) with a molecular weight of 350 (MPEG350) and a tumor-specific tetrapeptide (Gly-Phe-Leu-Gly) were grafted to cyclotriphosphazene. The present conjugate exhibited cytotoxicity lower than that of free doxorubicin (IC50 = 0,10 μM) but a reasonably higher in vitro cytotoxicity (IC50 = 1.1 μM) against the leukemia L1210 cell line probably due to its enzymatically controlled release.
A new biodegradable water-soluble phosphazene trimer–doxorubicin conjugate was synthesized and exhibited lower than free doxorubicin (IC50 = 0.10 μM) but reasonably high in vitro cytotoxicity (IC50 = 1.1 μM) against the leukemia L-210 cell line.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 15, 1 August 2005, Pages 3576–3579