کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1368534 | 981701 | 2016 | 6 صفحه PDF | دانلود رایگان |
The synthesis of various substituted triazole–indenoisoquinoline hybrids was performed based on a CuI-catalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl)propargylindenoisoquinolines was used as substrates for the construction of triazole–indenoisoquinoline–AZT conjugated via a click chemistry-mediated coupling with 3′-azido-3′-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazole hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole linker–indenoisoquinoline–AZT hybrids in KB and HepG2 cancer cell lines.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3652–3657