کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1368606 981704 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
One-pot synthesis and antifungal activity against plant pathogens of quinazolinone derivatives containing an amide moiety
ترجمه فارسی عنوان
سنتز یک قوطی و فعالیت ضد قارچی علیه پاتوژن های گیاهی مشتق های کوینازولینون حاوی آمید
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

An efficient one-pot, three-component synthesis of quinazolinone derivatives containing 3-acrylamino motif was carried out using CeO2 nanoparticles as catalyst. Thirty-nine synthesized compounds were obtained with satisfied yield and elucidated by spectroscopic analysis. Four phytopathogenic fungi were chosen to test the antifungal activities by minimum inhibitory concentration (MIC) method. Compounds 4ag, 4bb, 4bc showed broad antifungal activities against at least three fungi, and dramatic effects of substituents on the activities were observed. Docking studies were established to explore the potential antifungal mechanism of quinazolinone derivatives as the chitinase inhibitors, and also verified the importance of the amide moiety.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 9, 1 May 2016, Pages 2273–2277
نویسندگان
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