کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1368781 | 981726 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of the imidazole-derived GPR40 agonist AM-3189
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of the imidazole-derived GPR40 agonist AM-3189 Discovery of the imidazole-derived GPR40 agonist AM-3189](/preview/png/1368781.png)
چکیده انگلیسی
As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837.
As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and comparable in vivo efficacy.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 15–20
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 15–20
نویسندگان
Zhihua Ma, Daniel C.-H. Lin, Rajiv Sharma, Jinqian Liu, Liusheng Zhu, An-Rong Li, Todd Kohn, Yingcai Wang, Jiwen (Jim) Liu, Michael D. Bartberger, Julio C. Medina, Run Zhuang, Frank Li, Jane Zhang, Jian Luo, Simon Wong, George R. Tonn, Jonathan B. Houze,