کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1368870 981729 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives
چکیده انگلیسی

STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 18, 15 September 2014, Pages 4568–4574
نویسندگان
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