کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1368870 | 981729 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives](/preview/png/1368870.png)
چکیده انگلیسی
STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin’s lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 18, 15 September 2014, Pages 4568–4574
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 18, 15 September 2014, Pages 4568–4574
نویسندگان
Riccardo Rondanin, Daniele Simoni, Romeo Romagnoli, Riccardo Baruchello, Paolo Marchetti, Cristiana Costantini, Sara Fochi, Giacomo Padroni, Stefania Grimaudo, Rosaria Maria Pipitone, Maria Meli, Manlio Tolomeo,