Novel AI-2 quorum sensing inhibitors in Vibrio harveyi identified through structure-based virtual screening

In this letter, a high-throughput virtual screening was accomplished to identify potent inhibitors against AI-2 quorum sensing on the basis of Vibrio harveyi LuxPQ crystal structure. Seven compounds were found to inhibit AI-2 quorum sensing with IC50 values in the micromolar range, and presented low cytotoxicity or no cytotoxicity in V. harveyi.

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