Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors

A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.

A series of pyridoxine hydroxamic acid derivatives were prepared and evaluated as inhibitors of HIV integrase complex and wild type virus.Figure optionsDownload as PowerPoint slide