Design, synthesis and structure–activity relationships of 5-alkylaminolquinolines as a novel series of CRF1 receptor antagonists

A series of 5-alkylaminolquinolines was designed and synthesized as potential novel CRF1 receptor antagonists. The structure–activity relationships (SARs) of the substituents on each position (R2, R3, R5 and R5′) were investigated.

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