کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369647 981784 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Attenuation of collagen-induced arthritis by orally available imidazoline-based NF-κB inhibitors
چکیده انگلیسی

The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 14, 15 July 2012, Pages 4816–4819
نویسندگان
, , , , , , , , , ,