کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369891 981793 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
چکیده انگلیسی

A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure–activity relationships from lead structure C to optimized structure 3y are described. Compound 3y was evaluated in a rabbit PD-model and was found to selectively prolong the atrial effective refractory period at submicromolar concentrations.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 5, 1 March 2014, Pages 1269–1273
نویسندگان
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