کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370064 981807 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives
ترجمه فارسی عنوان
فعالیت های سنتز، ضد التهابی، زخمی و سیکلوکوسیژیناز مشتقات اندینوپییریمیدین
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Objective of the present work was to evaluate the anti-inflammatory, ulcerogenicity and cyclooxygenase activity of indenopyrimidine derivatives. Anti-inflammatory activity of the tested compounds is investigated by carrageenan-induced rat paw edema assay. Compounds A1, A6, A7 and A12 exhibit the comparable anti-inflammatory activity (79.33–81.33%) to the standard drug diclofenac sodium (85.33%), while A6, A7, A9, A12 and A14 show better ulcer index than the reference standard diclofenac sodium. To rationalize the anti-inflammatory activity, docking experiments are performed to study the ability of these compounds to bind into the active site of COX-2 enzyme.

The synthesized indenopyrimidine derivatives were screened for their anti-inflammatory, ulcerogenic and cyclooxygenase activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 3, 1 February 2016, Pages 814–818
نویسندگان
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