A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas

A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2–5) from the gorgonian coral Junceellajuncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2–5) did not exhibit the activity against fungi.

A new 8-hydroxy briarane diterpenoid was isolated from the gorgonian coral Junceella juncea, collected off Mandapam coast and its structure was established by 2D-NMR. The structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 it exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum).Figure optionsDownload as PowerPoint slide