کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1370730 981828 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
چکیده انگلیسی

A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited impressive antidepressant activity, measured in terms of percentage decrease in immobility duration (% DID). In addition, the active antidepressant compounds were subsequently studied at their most effective dose and activity of these compounds were confirmed in forced swimming test (FST) animal model, in which the compounds at a low dose of 0.5 mg/kg significantly decreased the immobility time and exhibited greater efficacy than the reference standards fluoxetine and imipramine. The potent compounds did not show any neurotoxicity in the rotarod test and the preliminary results are promising enough to warrant further studies around this scaffold.

A series of novel 3-phenylcoumarin derivatives have been synthesized and evaluated for their in vivo antidepressant activities. The most active compound 6 was selected as lead compound for further antidepressant research.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 7, 1 April 2011, Pages 1937–1941
نویسندگان
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