8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment

Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.

A new juglone derivative showed very promising activity, in terms of apoptotic versus necrotic cell death, compared to the reference drug temozolomide in glioma cells.Figure optionsDownload as PowerPoint slide