کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1370850 | 981830 | 2011 | 4 صفحه PDF | دانلود رایگان |
Bioactivity-guided isolation for the new/novel metabolites from the EtOAc extract obtained from the culture broth of a marine Bacillus sp. 09ID194 followed by chromatographic fractionations and subsequently HPLC purifications led to the isolation of two known macrolides, macrolactins A (1) and Q (2), together with a new glycosylated marcrolide, macrolactin W (3). The chemical structures of compounds 1–3 were assigned based on extensive MS and NMR spectral data analysis and literature review. Compound 3 showed potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria.
Macrolactin W (3), a new potent antibacterial macrolide, was isolated from a marine Bacillus sp. together with two known macrolactins A (1) and Q (2) through bioassay-guided isolation. The structure of this new macrolactin was determined by extensive MS, 1D and 2D NMR spectral data analysis. Macrolactin W is the first macrolactin where succinic acid moiety was fully esterified.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 12, 15 June 2011, Pages 3832–3835