Design and synthesis of 5,6-fused heterocyclic amides as Raf kinase inhibitors

Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan–Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.

Two scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan–Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.Figure optionsDownload as PowerPoint slide