A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2

Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.

A compound extracted from Forsythia suspensa specifically promoted shp2 activity in a dose-dependent manner and was identified as oleanolic acid (OA).Figure optionsDownload as PowerPoint slide