کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371158 981839 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines
چکیده انگلیسی

Phenyl-substituted indoloquinolines were studied for their biological activity and their DNA binding affinity. Water-soluble aminoalkyl derivatives were prepared and have shown significant in vitro anticancer activity. Unlike previous reports on the potential role of duplex DNA as target for various indoloquinoline based drugs, duplex UV melting experiments and fluorescence titrations suggest only weak and moderately strong binding of the phenyl-substituted indoloquinolines at 120 mM and 20 mM Na+ concentrations, respectively. Binding is suggested by ethidium displacement and circular dichroism experiments to be associated with drug intercalation between base pairs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 8, 15 April 2011, Pages 2380–2383
نویسندگان
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