کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1371356 | 981843 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors](/preview/png/1371356.png)
چکیده انگلیسی
A high throughput screen identified N-aroylpyrazoline 1 as a selective inhibitor of the V600E mutant of B-Raf kinase. Parallel synthesis of acyl, aroyl, and sulfonyl derivatives led to the identification of several potent inhibitors in both enzymatic and cellular (pERK) assays such as compound 42.
A high throughput screen identified N-aroylpyrazoline 1 as a selective inhibitor of the V600E mutant of B-Raf kinase. Parallel synthesis of acyl, aroyl, and sulfonyl derivatives led to the identification of several potent inhibitors in both enzymatic and cellular (pERK) assays such as compound 42.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 16, 15 August 2010, Pages 4795–4799
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 16, 15 August 2010, Pages 4795–4799
نویسندگان
Christopher Blackburn, Matthew O. Duffey, Alexandra E. Gould, Bheemashankar Kulkarni, Jane X. Liu, Saurabh Menon, Masayuki Nagayoshi, Tricia J. Vos, Juliet Williams,