New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy

The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK-NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods.

We report the synthesis, the conformational study by using CD spectroscopy and the antifungal assays of penetratin analogues. These peptides displayed a significant antifungal activity against Candida albicans and Cryptococcus neoformans.Figure optionsDownload as PowerPoint slide