کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1371435 981845 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists
چکیده انگلیسی

Novel 3-(1H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent CB1 cannabinoid receptor agonists. The oral bioavailability of these compounds could be dramatically improved by optimization studies of the side chains attached to the indole and oxadiazole cores, leading to identification of a CB1 receptor agonist with good oral activity in a range of preclinical models of antinociception and antihyperalgesia.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 6, 15 March 2011, Pages 1748–1753
نویسندگان
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