Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives

A series of novel coumarin bisindole heterocycles were synthesized following an uncommon method and evaluated for their antihyperlipidemic activity in hyperlipidemic hamster model. Among 12 compounds tested, the compound 5e showed potent antihyperlipidemic activity and was found to decrease the plasma triglyceride levels (TG) by 55%, total cholesterol (TC) by 20%, accompanied by an increase in HDL-C/TC ratio by 42% in hyperlipidemic rats to a greater degree than some of the reference statins.

The discovery of new series of coumarin bisindoles as potential antidyslipidemic agents is described.Figure optionsDownload as PowerPoint slide